Invited Speakers

A. Gefen

Tel Aviv University, Israel

The Role of Computer Methods in Pressure Ulcer Prevention

H. Van Oosterwyck

University of Leuven, Belgium

Modelling and measuring cell-matrix mechanical interactions

Alejandro Frangi

University of Sheffield, UK

Precision Population Imaging: scaling up our analytic ambitions

Jos Vander Sloten

Katholieke Universiteit Leuven, Belgium

Added value of case-specific, computer aided biomechanical analysis

Sandra Loerakker

Eindhoven University of Technology,
The Netherlands

Predicting growth and remodeling of engineered cardiovascular tissues

Michael S. Sacks

The University of Texas at Austin, USA

Multi-Resolution Models of the Mitral Heart Valve

C.P. Bourauel

University of Bonn, Germany

High Performance Polymers in Dentistry (Biomechanical and Clinical Aspects)

Marc Thiriet

Université Pierre et Maris Curie, France

Monolithic solver for blood flow in large valved veins of inferior limbs

Cristian A. Linte

Rochester Institute of Technology, USA

From medical image computing to computer-aided diagnosis tools: Successes, Challenges, Guidelines and Lessons Learned

Martyn Nash

University of Auckland, New Zealand

Biomechanical Mechanisms of Heart Failure

Daniela Iacoviello

Università degli Studi di Roma 'La Sapienza’, Italy

Physiological Cybernetics: Methods and Applications

P. Verdonck

University of Ghent, Belgium

Convergence & the MedTech ecosystem

Dominique P. Pioletti

EPFL, Switzerland

Hydrogel as a model system to study dissipation phenomena in soft tissue

S. Evans

Cardiff University, UK

Models of Soft Materials under Multiaxial Loading

Estevam de las Casas

Universidade Federal de Minas GeraisBrazil

Designing intramedullar posts for veterinary applications

S. Shirazi-Adl

École Polytechnique de Montréal, Canada

Knee Joint Response in Gait

Fiorella Sgallari

University of Bologna, Italy

Enhancing sparsity beyond convexity: applications to the restoration and segmentation of medical images and surfaces

W. Skalli

Laboratoire de Biomécanique, France

In vivo barycentremetry for subject specific musculo-skeletal modelling

Special Sessions

Dental Biomechanics

C.P. Bourauel; Ludger Keilig

> Click Here do read Special Session description

Dental biomechanics covers a wide range of loading conditions, starting from the functional loading during mastication, force application during orthodontic treatment to pathological loading during habits like clenching or grinding or even traumatic events. Additionally there is a large range of materials involved - hard tissue (like bone or teeth), soft tissues like the gingiva or the periodontal ligament with its complex structure, the temporomandibular joint, as well as the different materials that are introduced into the dental structures during restorative dental treatment or prosthodontics.

This mini-symposium offers a platform to present and discuss current aspects of dental biomechanics like (but not limited to)

• dedicated material models for the involved biological or
restorative materials,

• experimental determination of material properties of the
involved material in vitro or in vivo for the validation of such
material models,

• influence of (novel) material or design choices for
biomechanical behaviour of prosthodontic restorations, and

• application of bone modelling algorithms for orthodontic tooth
movement and for bone remodelling during implant treatment.

Bridging new Medical device technology towards the patiënt

P. Verdonck

> Click Here do read Special Session description

The overall aim of medical devices is to provide better treatment options or a better quality of life for the patient, and eventually to save lives. The absolute necessity of integrated thinking and a permanent dialogue between government, industry and hospitals while putting the patient centre stage. For researchers in this field, it means that they should be familiar with the complex valorisation process of a medical device and understand the functioning of health economics, cost efficiency and the creation of added value with new medical high-tech. For the government, it means that the many existing information channelsand financial resources should be communicated through one unique platform: the MedTech platform. The start-up SMEs active in Medical Technology (MedTech) all need eight policy lines:
1. Internal networking and visibility
2. Sharing heavy equipment and infrastructure
3. Knowledge of quality assurance and systems
4. Human Resources
5. Creation of hospital ecosystems for data collection and standardized patient data streams
6. Integration of refunding systems to penetrate domestic markets
7. Access to seed capital specifically for MedTech
8. Marketing / Business Coaching
All contributions streamlining these objectives are welcome.

Computational Modelling to understand cardiovascular pathologies

Eduardo Soudah

> Click Here do read Special Session description

The role of blood flow and its relationship with disease is crutial to understand cardiovascular pathologies, as vulnerable plaques, coronary disease, aortic disecction or aneurysms. For that, this mini-symposium want to cover:

- all the new development on computational modelling to evaluate vascular structures/blood flow and assess their physiological environment in diseased and interventional scenarios;
- blood flow simulations and shear stress-induced signaling,
- new implementing methods for the design and optimization of medical devices in endovascular therapies and;
- new computational tools to be useful in a clinical setting;

All contributions streamlining these objectives are welcome.

Computational modelling of cell mechanics

H. Van Oosterwyck; Bart Smeets

> Click Here do read Special Session description

Cell mechanics plays a crucial role in single cell and multicellular behaviour and organization, such as during morphogenesis, cell differentiation and diseases like cancer metastasis. Studying cell mechanics is complex, due to the active, dynamic nature of cell mechanical properties and the existence of feedback between chemical and mechanical regulators. Computational models of cell mechanical behaviour can help in elucidating the role of cell mechanics in physiology and pathophysiology. In this mini-symposium, we want to bring an overview of the current state of the art of cell mechanical models and their contribution to the study of single cell and multicellular behaviour. In addition, we want to emphasise the link to experimental methods that can provide data on cell mechanical properties that are crucial for the calibration and validation of such models.

Growth and Remodelling

C. W. J. Oomens; Sandra Loerakker; Michael Sachs 

> Click Here do read Special Session description

Tissue growth and remodeling are of paramount importance in many physiological and pathophysiological processes. Yet, the responsible mechanisms are only poorly understood. The fields of tissue engineering and regenerative medicine strongly rely on the intrinsic capacity of living tissues to grow and adapt in response to physical and chemical cues, in order to restore, maintain, or improve the functionality of living tissues and organs. It is evident that a fundamental understanding of the underlying growth and remodeling mechanisms is critical for the success of both fields and ensuring the safety and robustness of newly developed technologies in these areas. Due to the complexity of the processes involved, computational modeling plays a pivotal role in obtaining a mechanistic understanding of the interplay between mechanics and tissue adaptation.

This mini-symposium welcomes researchers to present and discuss experimental as well as computational aspects of growth and remodeling in biological tissues. This includes (but is not limited to):

Testing methods to explore the underlying mechanisms of growth and remodeling.

Computational tools to include growth and remodeling laws in the simulations on biological structures

Simulation of clinical problems involving growth and remodeling

New Mathematical Trends in Medical Imaging

Fiorella Sgallari; Alessandro Lanza; Serena Morigi

> Click Here do read Special Session description

The aim of this minisymposium is to bring together researchers in various aspects of mathematical image processing to share the latest developments in this field and to leverage the synergy between accademic research and real applicative interests in image processing. The minisymposium will cover two parts: the first is dedicated to mathematical developments in imaging focusing on variational models and emerging related optimization techniques; the second part is devoted to investigate several aspects of imaging science ranging from hardware design to image enhancement, from image representation to image understanding, from the point of view of experts working in the field. Variational models are getting popular for image processing and other imaging problems including inverse problems, image reconstruction and computer vision. The search for fast and robust algorithms to solve variational models, however, is an open challenge to the mathematical community due to complexity involved with: nonlinearity, non-smoothness of functional and solutions, non-convexity for the minimization, high-order derivatives within the functional, and large data size. Both the use of advanced optimization techniques and the development of new techniques are of fundamental importance for the success of elaborations in different imaging applications. This motivates this proposal to bring researchers from industrial and mathematical community to exchange and stimulate ideas in imaging sciences, to combine deep theoretical contributions with very relevant emerging practical applications.

Soft Tissue Mechanics

Sam Evans; Martyn Nash

> Click Here do read Special Session description

Understanding the mechanics of soft tissues remains one of the major frontiers of biomechanics.
This symposium will address the problems of mathematical models for soft tissues, computational methods and algorithms, measurement and identification of material parameters and practical applications.

Musculoskeletal Models and Applications

S. Shirazi-Adl; H. Schmidt

> Click Here do read Special Session description

Nowadays, model studies have emerged as valuable, robust and complementary tools, hand-in-hand with in vivo and in vitro studies, in search to estimate muscle forces and internal joint loads in complex musculoskeletal systems during various daily activities. These models are crucial in prevention, evaluation and treatment managements of different disorders. Solution algorithms, model reconstruction, collection of required input data, validation and applications are covered in this mini-symposium.

Modeling and simulations for describing mechanisms of action and determining efficacy of medical technologies and processes

Amit Gefen; Alon Wolf

> Click Here do read Special Session description

Computational modeling and simulations of the function of medical technologies and processes facilitate scientific research work where direct experimentation does not exist, is not feasible timewise or budget-wise, or is unethical. Adequate modeling allows to establish greater confidence in innovative medical technologies and products, especially if such are not yet thoroughly evaluated by means of randomized clinical trials, which may be too expensive or take too long to accomplish for technologies that are at an early phase of implementation. Additionally, modeling of the function of medical devices or processes can minimize reliance on animal experiments. These benefits speed up innovation by not only explaining mechanisms of action of new technologies, processes and products but also, by paving the way to a next generation of such devices, processes and equipment. Governmental regulatory bodies around the world, including for example the Food and Drug Administration (FDA) in the USA, are now requiring modeling and simulation work as standard practice in the process of submission of new technologies and products for evaluation and approval, which reflects understanding that there needs to be a balance between the number of patients necessary to evaluate diagnosis and treatment efficacies and the feasible investments that can be made by industry to push a technology or a process into the market for use by patients and medical practitioners. Furthermore, such regulatory bodies and the industry themselves are clearly moving towards relying on other scientific data sources, particularly computational models. This trend is clearly felt in fields where modeling was historically rather poorly adapted, such as cancer and wound prevention and care, where changes are taking place rapidly to adopt modeling of existing and new technologies and processes as a standard industry practice.

Combining Multibody and Finite Element Models for Anatomical Simulation

Sidney Fels; John Lloyd

> Click Here do read Special Session description

Models of anatomical structures commonly employ either a coarse grained approach using a multibody platform (e.g., OpenSim, AnyBody Adams) to combine rigid bodies, joints, and line-based muscles for simulating large scale motion and force behaviors, or a fine grained approach using a finite element (FEM) platform (e.g., FEBio, OpenCIMSS, ANSYS, Abaqus) to simulate deformation and stresses within the structure itself. In practice, it is often useful to combine these approaches: for example, one may employ an FEM model close to the area of interest while using a more computationally efficient multibody model of more distant structures to provide loads and gross motions.
Combined simulation can be effected using a system that supports both (e.g., ArtiSynth), or by connecting systems with an appropriate workflow.
This special session will provide a venue for discussing work related to combined multibody/FEM modeling, including (but not limited to):
* specific applications that have benefited from such an approach;
* technical and algorithmic challenges;
* software environments and workflows to facilitate combined simulation. Attendees who have encountered limitations with either 100% multibody or 100% FEM modeling will have an opportunity to consider how a hybrid approach might enhance their own research.

Non-invasive imaging of scoliosis 

Wafa Skalli; Claudio Vergari; Laurent Gajny

> Click Here do read Special Session description

Scoliosis is a complex three-dimensional deformity of the spine, including the spine and the ribcage. This pathology, that mostly affects adolescents, can be progressive and lead to respiratory or locomotor impairment and, more in general, to a decreased quality of life. Multiple medical imaging based examinations are usually required to characterize the pathology, plan its treatment or surgery and follow up its progression, which can be monitored for several years. Conventional radiography is the most common mean of imaging but its ionizing radiation is rightly an important concern to the adolescent population and their families. Although low-dose biplanar X-rays have partially solved this issue, the ALARP principle (“As Low As Reasonably Practicable”) guides us toward non-invasive or mini-invasive imaging techniques in scoliosis research. In this mini-symposium, we want to highlight new trends and research in non-invasive medical imaging in order to assess patient-specific scoliosis characteristics.

Functional Performance of Joint Arthroplasty

Richard M. Hall; Anthony Redmond

> Click Here do read Special Session description

The goal of this session is to provide an overview of the performance of joint implants, in arthroplasty applications, employing multi-scale computational modelling. The session provides for a diverse set of modelling systems including (1) biomechanical models of the articulating joint systems, and (2) surface wear models to assess implant performance. Simulation models can incorporate population modelling and a validation framework will be developed for their future maintenance and extension. The application of these models in device design and testing will be explored. The session provides an opportunity to present material including:
(1) Motion capture and the validation of such data in persons with arthroplasty
(2) Musculoskeletal models for the prediction of wear and joint failure in joint arthroplasty
(3) Computational wear predictions
(4) Tribological wear models in dry and mixed lubrication modes
(5) Prediction of material performance in arthroplasty.


Combined Multibody and Finite Element Simulation Using ArtiSynth

Sidney Fels; John Lloyd

> Click here for more information

ArtiSynth is a free, open source 3D modeling system developed at the University of British Columbia that combines multibody and finite element (FEM) simulation capabilities, including contact and constraints. It provides a highly interactive platform that lets users view and inspect their models while simultaneously running them. It is currently being used by a diverse set of research groups for a variety of applications including musculo-skeletal modeling of the foot, lower limb, spinal region, arm, and shoulder; function modeling of swallowing, mastication and speech; and preliminary studies of surgical treatment planning involving the head and neck region.
This workshop will provide an overview of ArtiSynth and its capabilities, combined with a hands-on tutorial in which attendees can evaluate how it may be used to further their research goals. Specific use cases will be presented to provide concrete illustrations of how it may be used. Attendees will be able to download ArtiSynth and experiment with it beforehand, and we will be available to answer any specific questions that they may have.
ArtiSynth models are primarily implemented using the Java programming language, providing users with a very powerful means to assemble complex and detailed models containing highly customized components and methods. Complete information about ArtiSynth, along with instructions for installing and using it, is available at

From Reality to Virtuality

BETA CAE Systems International AG

> Click here for more information

When reality is ahead of the simulation reverse engineering is necessary to create the virtual model out of the physical one. During this workshop the reverse engineering process will be presented with the aid of the tools of BETA CAE SYSTEMS AG, starting from the output data of an industrial tomograph and resulting to a ready to run solver file.
If internal structures are equally important as the external surfaces, the use of a tomograph for the 3D scanning is a necessity. RETOMO is the reliable tool for going from tomography voxels to virtual prototypes. With its streamed image processing technology it can process large datasets and deliver effortlessly large FE-Models, ready for pre-processing.
Pre-processing involves the creation of a high quality FE-Mesh and the definition of material properties, initial and boundary conditions for the simulation. In our case the simulation will be the virtual compression test of a cubic sample of a cancellous bone. During this workshop we will not only focus on the creation of a simple loadcase, but advanced modelling techniques will be demonstrated as well, by presenting the capabilities of ANSA for model reusability and automation.

LLJ – LifeLongJoints – Assessments in Orthopaedics

LLJ – LifeLongJoints

> Click here for more information

Recent results from metal on metal prostheses demonstrated that standards used to assess such prostheses provided little indication of the resulting failure in vivo. Whilst new standards have been agreed they are formed in retrospective manner and denote one of many perhaps possible failure modes. However, the global capacity of simulator testing in insufficient for testing all possible scenarios. Computational simulation may provide a methodology aiding the assessment of joint replacement performance in terms of identifying deleterious scenarios and predicting the levels of wear in these cases. The workshop will discuss these and other issues.

LifeLongJoints Introduction, Richard M Hall – 15 mins
Virtual Patient, Stephen Ferguson – 30 mins
Motion Capture, David Lunn – 30 mins
Wear Prediction, Nilanjan Das Chakladar – 30 mins

Working with C-Motion’s Dynamic Stereo X-ray Software Suite

C-Motion Biomechanics Software

> Click here for more information

Advances in diagnostic imaging have greatly improved our ability to detect structural changes in musculoskeletal tissues. There is now evidence that subtle joint translations of only a few millimeters are critical to estimating key clinical measures such as tissue stress, joint impingement, or implant kinematics during loaded functional movements. Dynamic Stereo X-ray (DSX) is the only currently available technology that can achieve sub-millimeter accuracy for a wide variety of functional movements. This workshop shows attendees how to use C-Motion's new DSX Software Suite to calibrate their equipment, correct X-ray images, and track multiple bones in the images.

This workshop will expain:
1. Calculating the 3D pose of the X-ray sources and image planes from images of the calibration object, including uniformity-corrections, distortion-corrections, and X-ray image resizing.
2. Using bone models extracted from CT, define anatomically meaningful reference frames, add landmarks, and define regions of interest. Track bones in X-ray trials using single frame or 4D optimization.
3. Export bone tracking to Visual3D for joint animations and kinematic analysis, including the calculation of joint congruency and ligament lengths. Validate markerless bone tracking with bead tracking.

Image-Based Modelling with Simpleware for Biomechanics


> Click here for more information

Image-based modelling from 3D scans (MRI, CT, mCT and more) enables detailed analysis and simulation of complex biomechanics problems. Join this workshop to learn about the key techniques, benefits, and opportunities offered by image-based modelling using Simpleware software. Explore the software’s many applications in biomechanics, including patient-specific implant designs, orthopaedics research, human body models, and many more. Discover common workflows and see how Simpleware has been used for specific biomechanics case studies to solve a variety of modelling challenges.

Scientific Programme

(Click here to see more)

Instructions for Presenters:

Instructions for oral presentations

- Each oral presentation will take 15 minutes including discussion.

- The files required for the presentation (PowerPoint or PDF) should be uploaded, and tested to ensure compatibility, during the coffee or lunch breaks before the beginning of the session.

- The lecture rooms contain a Windows 10 PC, with Office 2016 and Acrobat PDF Reader, connected to a data projector. The use of personal computers is not recommended.

- Technical support will be provided on-site by the CMBBE 2018 staff to ensure a smooth delivery of all oral presentations.

Instructions for poster presentations

- Posters will be displayed on vertical boards with maximum dimensions of 900mm (width) x 1200mm (height), which corresponds approximately to a standard A0-portrait.

- During the Poster Session the authors should be next to their posters.

Social Programme

Welcome Reception - Monday, 26th March - 18:30

Welcome reception will take place at conference site.

Tour visit to Cascais/Sintra - Wednesday, 28th March - 14:30

Buses will depart from IST (Rua Alves Redol) at 14:30. Please be there 10 minutes before the departure time and don’t forget to bring your Tour/ Dinner Voucher.We will depart to Cascais a cosmopolitan former fishing village, that in the 1940’s was chosen as residence by exiled European Royalty, a stop will be made by the lovely bay filled with fishing boats.
The tour will continue by coast line of Guincho, with its superb beach areas, cliffs and where, close by, is located Cape Roca, the westernmost point of Continental Europe. It continues to Sintra, a small delightful town in the forest covered Mountain of Sintra, immortalized as “Glorious Eden” by the World famous poet Lord Byron.

Conference Dinner

The dinner will take place at Penha Longa Monastery. (Quinta da Penha Longa, Estrada da Lagoa Azul, Sintra)

The Monastery was founded in 1355 by Friar Vasco Martins that introduced the St. Jeronimos Order in Portugal.In 1400 a church was built consecrated to Our Lady of Health. During the 15th and 16th centuries, Penha Longa was chosen by the Royal Family as a place for hunting, during the summer.Memories of strong presences, such as King D. Manuel (1496) and King D. Sebastião (1580). During this period, a Palace to host the Kings and their guests, fountains and gardens, oratories and watermills were built.


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